How long is treatment with ibrutinib?

Median duration of ibrutinib therapy was 41 months (range, 2–51 months). Among the 21 patients who came off therapy, the median survival after treatment discontinuation was 8 months.

How long does ibrutinib work for CLL?

The average duration of Imbruvica therapy in CLL clinical trials has been around 41 months (range, 2–51 months).

How effective is ibrutinib for CLL?

Ibrutinib produces durable responses in most patients with CLL, but a significant proportion of patients treated with single-agent ibrutinib experienced CLL progression: 15.5% of treatment-naïve patients and 20.9% of patients with relapsed/refractory disease13,15.

Does ibrutinib lower immune system?

Ibrutinib significantly decreased pathologically high circulating B cells, regulatory T cells, effector/memory CD4+ and CD8+ T cells (including exhausted and chronically activated T cells), natural killer (NK) T cells, and myeloid-derived suppressor cells; preserved naive T cells and NK cells; and increased circulating …

How many patients have been treated with ibrutinib?

Ibrutinib is indicated for the treatment of CLL/SLL, including del(17p) CLL/SLL, and allows for treatment without chemotherapy. This integrated analysis was performed to evaluate outcomes in 230 patients with relapsed/refractory del(17p) CLL/SLL from three ibrutinib studies.

Is there a cure for 17p deletion in CLL?

17p Deletion in CLL. When a patient is young enough, they should definitely consider a stem cell transplant for 17p deleted disease. The challenge though is that CLL more commonly affects patients too old for transplant. The engineered T cells hold some promise for being active in this setting.

Which is better for CLL idelalisib or ibrutinib?

It can have a tremendous impact on CLL prognosis and the FDA has recently extended approval to ibrutinib in this population (even without prior treatment) and the European equivalent of the FDA (the EMA) will do the same for idelalisib in combination with rituximab.

Are there patients with 17p deletion in p53?

This is important because patients with 17P deletion are not the only individuals who have to be concerned about it. About 30 percent of patients with abnormality in P53 have a mutation BUT NO DELETION.