What is H3 hemagglutinin?

Influenza hemagglutinin (H3 serotype) was the first glycoprotein structure to be solved at atomic resolution, by Ian Wilson, John Skehel and Don Wiley in 1981.

What is stalk domain?

The stalk domain includes two portions, from D18 to L58 (the N-terminus of HA1) and N293 to Q529 (the C-terminus of HA1 plus the ectodomain of HA2) for H1N1 viruses, Q17 to I67 and I294 to W530 for H3N2 viruses, and D16 to F56 and D307 to T548 for influenza B viruses.

How many amino acids are in hemagglutinin?

Hemagglutinin Structure HA is an homotrimer integral membrane glycoprotein. Each monomer is synthesized like a single polypeptide chain almost 550 amino acids.

What is the h3 virus?

Influenza A (H3N2) Variant Virus Influenza A H3N2 variant viruses (also known as “H3N2v” viruses) with the matrix (M) gene from the 2009 H1N1 pandemic virus were first detected in people in July 2011. The viruses were first identified in U.S. pigs in 2010. During 2011, 12 human infections with H3N2v were detected.

Where is hemagglutinin located in a virus?

Hemagglutinin (HA) or Haemagglutinin (BE) is an antigenic glycoprotein found on the surface of the influenza viruses. It is responsible for binding the virus to the cell that is being infected.

What does the 1 in H1N1 stand for?

The designation “H1N1” indicates unique traits, which exhibit characteristics that identify the virus to the immune system and allows for attachment and replication of the virus. The “H” (hemagglutinin) and the “N” (neuraminidases) are both proteins that are found on the outer shell or envelope of the virus.

What does hemagglutinin do in viruses?

The hemagglutinin glycoprotein of influenza virus has important functions in the initiation of infection: it mediates adsorption of the virus particles to cell surface receptors and is responsible for the subsequent uncoating of the virus by a process of fusion between viral and host membranes.

Is H3N2 a swine flu?

Regularly circulating in North American swine, common strains of swine influenza include H1N1, H1N2 and H3N2.

Why does the H5N1 virus contain hemagglutinin?

The hemagglutinin of the H5N1 virus has been associated with the high pathogenicity of this flu virus strain, apparently due to its ease of conversion to an active form by proteolysis. HA is a homotrimeric integral membrane glycoprotein.

What kind of activity does hemagglutinin have?

Hemagglutinin is a Class I Fusion Protein, having multifunctional activity as both an attachment factor and membrane fusion protein.

How does an antibody against hemagglutinin work?

Some antibodies against hemagglutinin act by inhibiting attachment. This is because these antibodies bind near the top of the hemagglutinin “head” (blue region in figure above) and physically block the interaction with sialic acid receptors on target cells.

What is the structure of the hemagglutinin monomer?

Structure. HA is a homotrimeric integral membrane glycoprotein. It is shaped like a cylinder, and is approximately 13.5 nanometres long. HA trimer is made of three identical monomers. Each monomer is made of an intact HA0 single polypeptide chain with HA1 and HA2 regions that are linked by 2 disulfide bridges.