What is a high Oncotype DX score?

The score is a number between 0-100. A low score means the cancer has a lower chance of returning and you have a lower chance of benefiting from chemotherapy. A high score means the cancer has a higher chance of returning and you have a higher chance of benefiting from chemotherapy.

What does an Oncotype score of 12 mean?

Oncotype DX testing was done on tissue samples from 2,568 cancers: 15.3% had a Recurrence Score of 11 or lower (defined by the researchers as a low risk of recurrence) 60.4% had a Recurrence Score of 12 to 25 (defined by the researchers as an intermediate risk of recurrence.

What does an Oncotype score of 20 mean?

Recurrence Score of 16-20: The cancer has a low to medium risk of recurrence. The benefits of chemotherapy likely will not outweigh the risks of side effects. Recurrence Score of 21-25: The cancer has a medium risk of recurrence.

What does Oncotype score of 0 mean?

Recurrence Score of 0-25: The cancer has a low risk of recurrence. The benefits of chemotherapy likely will not outweigh the risks of side effects. Recurrence Score of 26-100: The cancer has a high risk of recurrence. The benefits of chemotherapy are likely to be greater than the risks of side effects.

How reliable is the Oncotype test?

A large population-based observational study based on the SEER registry of more than 40,000 node-negative and 4,500 node-positive patients who received the Oncotype DX test in clinical settings showed Breast Cancer Specific Mortality (BCSM) at five years was less than half a percent in node negative disease and one …

How is Oncotype score calculated?

The original Magee equation is represented as follows: recurrence score=13.424+5. 420*(nuclear grade)+5.538*(mitotic count)−0.045*(ER H-score)−0.030*(PR H-score)+9.486*(0 for negative/equivocal and 1 for HER2 positive).

How accurate is oncotype?

How long does it take to get Oncotype score back?

How long will it take to get the results of the Oncotype DX test? Your cancer tissue will be sent to a special laboratory where it will be analyzed. It will take about 2 weeks for your doctor to get the results. You will then be able to discuss the results with your doctor.

What does an Oncotype score of 25 mean?

A score between 0 and 25 means you have a low risk of the cancer returning if you get hormone treatment. With this score you probably will not benefit from receiving chemotherapy. A score between 26 and 100 means you have a higher risk that the disease might come back.

How is the recurrence score of Oncotype DX determined?

The Recurrence Score result is based on the quantitative analysis of the expression of 21 genes within the patient’s tumor sample. Patient’s individualized risk of distant recurrence when treated with endocrine therapy alone.* *based on the TAILORx or NSABP B-14 Trials.

Can a hormone positive woman get Oncotype DX?

The Intergroup Trial E2197 reported that Oncotype DX identifies women with hormone positive, HER2-negative breast cancer with 0-3 positive axillary nodes who are at a 3-4 fold increase in the risk of relapse despite standard chemotherapy and hormonal therapy.

Are there any Oncotype DX tests for breast cancer?

Based on your unique information, Breastcancer.org can recommend articles that are highly relevant to your situation. There are two types of Oncotype DX tests: The Oncotype DX Breast Recurrence Score Test for people diagnosed with early-stage, estrogen-receptor-positive, HER2-negative invasive breast cancer

Is there a role for Oncotype DX testing in invasive lobular carcinoma?

Conlon N et al, Is There a Role for Oncotype Dx Testing in Invasive Lobular Carcinoma?Breast J. 2015 Sep-Oct;21 (5):514-9. A recent study said: Our results showed that RS has not been completely embraced in the management of MBC, although when performed in MBC, chemotherapy recommendations vary based on RS.