What interferes with folate metabolism?

A number of drugs such as aminopterin, methotrexate (amethopterin), pyrimethamine, trimethoprim and triamterene act as folate antagonists and produce folate deficiency by inhibiting this enzyme.

Where is folic acid metabolized?

Folate

What is impaired folate metabolism?

Collapse Section. Hereditary folate malabsorption is a disorder that interferes with the body’s ability to absorb certain B vitamins (called folates) from food. Folates are important for many cell functions, including the production of DNA and its chemical cousin, RNA.

Why folate is essential for human metabolism?

Adequate folate intake is vital for cell division and homeostasis due to the essential role of folate coenzymes in nucleic acid synthesis, methionine regeneration, and in the shuttling, oxidation and reduction of one-carbon units required for normal metabolism and regulation (Wagner 1995).

Can folic acid be taken with malaria drug?

Folic acid reverses the inhibition by antifolate drugs of plasmodial growth or survival in vitro, and folic acid supplements given to children with malaria may increase the failure rate of treatment with antimalarials.

How long is folate stored in the body?

Your body’s store of folate is usually enough to last 4 months. This means you need folate in your daily diet to ensure your body has sufficient stores of the vitamin.

Can you take Fansidar if you have folic acid deficiency?

Fansidar has not been reported to interfere with antidiabetic agents. If signs of folic acid deficiency develop, Fansidar should be discontinued.

What is the name of the folic acid antagonist in Fansidar?

Sulfadoxine and pyrimethamine, the constituents of Fansidar, are folic acid antagonists. Sulfadoxine inhibits the activity of dihydropteroate synthase whereas pyrimethamine inhibits dihydrofolate reductase.

How often should you take leucovorin for folic acid deficiency?

When recovery of depressed platelets or white blood cell counts in patients with drug-induced folic acid deficiency is too slow, folinic acid (leucovorin) may be administered in doses of 5 to 15 mg intramuscularly daily for 3 days or longer.

What are the effects of Fansidar on Plasmodium falciparum?

Sulfadoxine inhibits the activity of dihydropteroate synthase whereas pyrimethamine inhibits dihydrofolate reductase. Sulfadoxine and pyrimethamine are active against the asexual erythrocytic stages of Plasmodium falciparum. Fansidar may also be effective against strains of P. falciparum resistant to chloroquine.