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What does PPAR gamma do?

What does PPAR gamma do?

Activation of PPAR-γ causes insulin sensitization and enhances glucose metabolism, whereas activation of PPAR-β/δ enhances fatty acids metabolism. Thus, PPAR family of nuclear receptors plays a major regulatory role in energy homeostasis and metabolic function.

Is PPAR gamma good?

Besides an impact on weight gain, reduced fluid retention may also lower the risk for adverse cardiovascular events, such as congestive heart failure. Although it is expressed at low levels in the heart, the expression of PPARγ is increased in the hearts of humans with metabolic syndrome84.

Is PPAR gamma a transcription factor?

PPAR-γ: a thrifty transcription factor.

Which drug is PPAR gamma activator?

PPAR gamma, agonists

Drug Target Type
AMG-131 Peroxisome proliferator-activated receptor gamma target
Muraglitazar Peroxisome proliferator-activated receptor alpha target
Muraglitazar Peroxisome proliferator-activated receptor gamma target
Muraglitazar Cytochrome P450 1A2 enzyme

What activates PPAR?

Endogenous ligands for the PPARs include free fatty acids, eicosanoids and Vitamin B3. PPARγ is activated by PGJ2 (a prostaglandin) and certain members of the 5-HETE family of arachidonic acid metabolites including 5-oxo-15(S)-HETE and 5-oxo-ETE.

What activates PPAR alpha?

PPAR-α is a transcription factor and a major regulator of lipid metabolism in the liver. PPAR-alpha is activated under conditions of energy deprivation and is necessary for the process of ketogenesis, a key adaptive response to prolonged fasting.

What is adiponectin function?

Adiponectin is a fat-derived hormone that appears to play a crucial role in protecting against insulin resistance/diabetes and atherosclerosis. Decreased adiponectin levels are thought to play a central role in the development of type 2 diabetes, obesity and cardiovascular disease in humans.

What drug activates PPAR alpha?

PPAR alpha, agonists

Drug Target Type
Elafibranor Peroxisome proliferator-activated receptor gamma target
Muraglitazar Peroxisome proliferator-activated receptor alpha target
Muraglitazar Peroxisome proliferator-activated receptor gamma target
Muraglitazar Cytochrome P450 1A2 enzyme