Is example of piperazine derivatives?
Is example of piperazine derivatives?
The piperazine derivatives include 1-benzylpiperazine (BZP), 1,3-trifluoromethylphenylpiperazine (TFMPP), 1-(3-chlorophenyl) piperazine (mCPP) and 1-(4-methoxyphenyl) piperazine (MeOPP); a full summary of their chemical properties is presented in the ‘Physical Descriptions’ section.
What are piperazine derivatives?
Piperazine compounds are derivatives of piperazine (1), a cyclic molecule containing two nitrogen atoms in positions 1 and 4 as well as four carbon atoms 1, 4-6 (Figure 1). Figure 1. Chemical structure of piperazine nuclei (1).
Which of the following drug is piperazine derivatives?
Diethylcarbamazine, a derivative of piperazine, is used to treat some types of filariasis.
What is piperazine for?
Anthelmintics are used in the treatment of worm infections. Piperazine is used to treat: common roundworms (ascariasis) and. pinworms (enterobiasis; oxyuriasis).
Which derivative is benzimidazole?
A benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections….Benzimidazole Derivatives.
| Drug | Target | Type |
|---|---|---|
| Albendazole | Tubulin alpha-1A chain | target |
| Albendazole | Tubulin beta-4B chain | target |
| Albendazole | Cytochrome P450 3A4 | enzyme |
| Albendazole | Fumarate reductase flavoprotein subunit | target |
What is a piperazine ring?
Piperazine (1,4-hexahydropyrazine) is a cyclic organic molecule possessing two nitrogen atoms in opposite positions within a 6-member heterocyclic ring.
What are the side effects of piperazine?
Side Effects
- Blurring of vision.
- clumsiness.
- crawling or tingling feeling of the skin.
- irregular, twisting movement, especially of the face, arms, and legs.
- joint pain.
- skin rash or itching.
What is the function of benzimidazole?
The benzimidazole and its derivatives play a very important role as a therapeutic agent e.g. antiulcer and anthelmintic drugs. Apart from this the benzimidazole derivatives exhibit pharmacological activities such as antimicrobial, antiviral, anticancer, anti-inflammatory, analgesic, etc.
Is benzimidazole basic?
Benzimidazole is a base: It can also be deprotonated with stronger bases: C6H4N(NH)CH + LiH → Li [C6H4N2CH] + H.
Is there such a thing as a piperazine derivative?
Piperazine Derivatives are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. Yes! I am interested
What can piperazine be used for in medicine?
Some of these therapeutic areas include antifungals, antidepressants, antiviral, and serotonin receptor (5-HT) antagonists/agonists. Simple N-substituted piperazines are found in numerous drug molecules. CDH has a good selection of piperazine compounds that can be used as building blocks for organic synthesis and medicinal chemistry.
What is the name of the anthelmintic drug piperazine?
These drugs are often referred to simply as “piperazine” which may cause confusion between the specific anthelmintic drugs, the entire class of piperazine-containing compounds, and the compound itself. Diethylcarbamazine, a derivative of piperazine, is used to treat some types of filariasis .
How is piperazine separated from the product stream?
Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially. The piperazine is separated from the product stream, which contains ethylenediamine, diethylenetriamine, and other related linear and cyclic chemicals of this type.