How do you store amphotericin B injections?

The concentrate (5 mg amphotericin B per mL after reconstitution with 10 mL Sterile Water for Injection USP) may be stored in the dark, at room temperature for 24 hours, or at refrigerator temperatures for one week with minimal loss of potency and clarity. Any unused material should then be discarded.

How do you give liposomal amphotericin B?

Vials of AmBisome containing 50 mg of amphotericin are prepared as follows:

1. Add 12 ml of Sterile Water for Injection to each AmBisome vial, to yield a preparation containing 4 mg/ml amphotericin.
2. IMMEDIATELY after the addition of water, SHAKE THE VIAL VIGOROUSLY for 30 seconds to completely disperse the AmBisome.

What is the generic name for amphotec?

AMPHOTERICIN/LIPID COMPLEX – INJECTION (Abelcet, Ambisome, Amphotec) side effects, medical uses, and drug interactions.

Why must amphotericin B be given intravenously?

FUNGIZONE (amphotericin b) Intravenous is specifically intended to treat potentially life-threatening fungal infections: aspergillosis, cryptococcosis (torulosis), North American blastomycosis, systemic candidiasis, coccidioido-mycosis, histoplasmosis, zygomycosis including mucormycosis due to susceptible species of …

Does amphotericin B require dilution?

Dilute each ‘mg’ of drug with 10 ml. [1 mg/ 10 ml ] [4 – 6 hours] * dilute the reconstituted solution with 250-500 mL D5W; final concentration should not exceed 0.1 mg/mL (peripheral infusion) or 0.25 mg/mL (central infusion). Add 10 mL of SWFI (without a bacteriostatic agent) to each vial of amphotericin B.

Can amphotericin B be mixed with normal saline?

Procedure: Prehydration: Give 1 litre of Normal Saline with 1 amp (20mmol) of KCl infused over 2 hours before the Amphotericin B infusion. This reduces the risk of renal toxicity and hypokalaemia, both side effects of Amphotericin B. This should preferably be given from 8am to 10am.

What is the use of liposomal amphotericin B injection?

Amphotericin B liposomal injection is used to treat fungal infections such as cryptococcal meningitis (a fungal infection of the lining of the spinal cord and brain) and visceral leishmaniasis (a parasitic disease that usually affects spleen, liver, and bone marrow) in certain people.

What drug is a lipid complex?

Amphotericin B lipid complex injection is used to treat serious, possibly life-threatening fungal infections in people who did not respond or are unable to tolerate conventional amphotericin B therapy. Amphotericin B lipid complex injection is in a class of medications called antifungals.

How long should amphotericin B be administered?

Amphotericin B is injected into a vein through an IV. A healthcare provider will give you this injection. The medicine must be given slowly through an IV infusion, and can take from 2 to 6 hours to complete.

What is the most serious side effect of amphotericin?

The principal acute toxicity of AmB deoxycholate includes nausea, vomiting, rigors, fever, hypertension or hypotension, and hypoxia. Its principal chronic adverse effect is nephrotoxicity. AmB probably produces renal injury by a variety of mechanisms.