Can azathioprine cause shortness of breath?

Can azathioprine cause shortness of breath?

Azathioprine can cause a severe allergic reaction. Symptoms may include: trouble breathing.

Can azathioprine cause lung problems?

Azathioprine (AZA), an immunosuppressive purine analogue, is a lesser known cause, with 37 known reports listed in online databases. Its most common adverse effect is bone marrow suppression. The mechanism for pulmonary toxicity is unknown, but may involve bioactivation in the lung.

Can azathioprine cause lung fibrosis?

Biopsies showing hyaline membranes, intraalveolar edema and cuboidalization of alveolar epithelium were associated with total doses from 2,850 to 4,355 mg, whereas atypical epithelial hyperplasia, reorganization of distal air spaces, and fibrosis were noted in cases receiving from 5,600 to 28,625 mg of azathioprine.

Does azathioprine cause interstitial lung disease?

Azathioprine is a commonly prescribed therapy for connective tissue disease-associated interstitial lung disease (CTD-ILD). Combination therapy that included azathioprine was recently shown to increase the risk of death and hospitalization in patients with idiopathic pulmonary fibrosis.

Does azathioprine cause a cough?

Some people can have serious side effects when taking azathioprine. Stop taking your medicine and contact your specialist or a doctor immediately if: you feel tired all the time, dizzy or sick, or you are vomiting or have diarrhoea. you have a high temperature with shivering or chills, cough or a sore throat.

What are the side effects of azathioprine?

What are the possible side effects of azathioprine (Imuran®)?

  • Increased stomach irritation, abdominal pain.
  • Nausea and vomiting.
  • Changes in hair color and texture, along with hair loss.
  • Loss of appetite.
  • Blood in the urine or stool.
  • Unusual bruising.
  • Fatigue.
  • Development of mouth sores and ulcers.

Can you take prednisone with azathioprine?

No interactions were found between azathioprine and prednisone.

What to avoid while on immunosuppressants?

Basic Guidelines to Follow

  • Avoid raw or rare meat and fish and uncooked or undercooked eggs.
  • Thoroughly cook eggs (no runny yolks) and avoid foods containing raw eggs such as raw cookie dough or homemade mayonnaise.
  • Avoid unpasteurized beverages, such as fruit juice, milk and raw milk yogurt.

Are there any long term side effects of azathioprine?

Frequency and severity of side effects depend on dose and duration of azathioprine as well as on underlying disease or concomitant therapies. Hematologic toxicities and neoplasia were reported more often in renal homograft recipients than in patients using azathioprine for rheumatoid arthritis. [ Ref]

What are the side effects of azathioprine in dogs?

The side effects are lethargy, fever, reluctance to move, and a decrease in appetite. Dogs are much more unwilling to move around when they take this drug. More so than other animals.

What kind of disease is azathioprine used for?

Azathioprine ( AZA ), sold under the brand name Imuran among others, is an immunosuppressive medication. It is used in rheumatoid arthritis, granulomatosis with polyangiitis, Crohn’s disease, ulcerative colitis, systemic lupus erythematosus, and in kidney transplants to prevent rejection. It is taken by mouth or injected into a vein.

What’s the maximum dose of azathioprine you can take?

Maximum dose: 2.5 mg/kg orally or IV per day. Duration: At least 12 weeks. Comments: -Dose may be increased by 0.5 mg/kg/day (or approximately 25 mg/day), after 6 to 8 weeks of starting treatment and thereafter at 4 week intervals if necessary. -Gradual dose reduction is recommended to reduce the risk of toxicities.