Which is the chemotherapy agents act by intercalation?

DNA intercalators are used in chemotherapeutic treatment to inhibit DNA replication in rapidly growing cancer cells. Examples include doxorubicin (adriamycin) and daunorubicin (both of which are used in treatment of Hodgkin’s lymphoma), and dactinomycin (used in Wilm’s tumour, Ewing’s Sarcoma, rhabdomyosarcoma).

Which class of drugs disrupts DNA by intercalation?

Actinomycin D interferes with both DNA replication and transcription by intercalation between bases. It is most commonly used as a chemotherapeutic (anticancer) agent to treat gestational trophoblastic neoplasia, Wilms’ tumor, and rhabdomyo-sarcoma.

Is cisplatin an intercalator?

Cisplatin is an intercalating agent that induces apoptosis of cancer cells, and it has been the most widely used drug in the first-line chemotherapy.

What does an intercalating agent do?

A substance that inserts itself into the DNA structure of a cell and binds to the DNA. In cancer treatment, DNA intercalating agents may kill cancer cells by damaging their DNA and stopping them from dividing.

How does DNA intercalation work?

A substance that inserts itself into the DNA structure of a cell and binds to the DNA. This causes DNA damage. In cancer treatment, DNA intercalating agents may kill cancer cells by damaging their DNA and stopping them from dividing.

How does an intercalating agent introduce a mutation?

Intercalating agents are another type of chemical mutagen. They tend to be flat, planar molecules like benzo[a]pyrene, a component of wood and tobacco smoke, and induce mutations by inserting between the stacked bases at the center of the DNA helix.

What are the side effects of cisplatin?

Common side effects of cisplatin

• Risk of infection. This treatment can reduce the number of white blood cells in your blood.
• Bruising and bleeding.
• Anaemia (low number of red blood cells)
• Feeling sick.
• Loss of appetite.
• Changes to your taste.
• Effects on the kidneys.
• Changes in hearing.

What are the long term effects of cisplatin?

Cisplatin (CDDP) is a frequently employed chemotherapeutic drug both in curative and palliative settings. When cancer patients are cured due to CDDP therapy, they unfortunately often experience severe long‐term side effects including irreversible hearing loss (ototoxicity) and permanent neuronal and renal damage.