What does neurofilament light chain do?

Neurofilament light chain is a biomarker that can be measured with immunoassays in cerebrospinal fluid and plasma and reflects axonal damage in a wide variety of neurological disorders.

What is Nefl gene?

NEFL (Neurofilament Light Chain) is a Protein Coding gene. Diseases associated with NEFL include Charcot-Marie-Tooth Disease, Axonal, Type 2E and Charcot-Marie-Tooth Disease, Demyelinating, Type 1F. Among its related pathways are RET signaling and Post NMDA receptor activation events.

What is nf light?

The Simoa NF-light™ assay is a digital immunoassay for the quantitative determination of NfL in serum, plasma and CSF. The antibodies also cross react with murine, bovine, and macaque NfL epitopes, and the assay can be used for research with these species.

Where are Neurofilaments found?

cytoplasm
Neurofilaments (NF) are classed as type IV intermediate filaments found in the cytoplasm of neurons. They are protein polymers measuring 10 nm in diameter and many micrometers in length. Together with microtubules (~25 nm) and microfilaments (7 nm), they form the neuronal cytoskeleton.

Where is neurofilament located?

Which is the shortest filament from the cell body?

Neurofilaments (NF) are classed as type IV intermediate filaments found in the cytoplasm of neurons. They are protein polymers measuring 10 nm in diameter and many micrometers in length.

Which is the longest filament from the cell body?

Microtubules are the largest type of filament, with a diameter of about 25 nanometers (nm), and they are composed of a protein called tubulin.

What is the neurofilament light polypeptide ( NEFL )?

Neurofilament light polypeptide, also known as neurofilament light chain, is a neurofilament protein that in humans is encoded by the NEFL gene. Neurofilament light chain is a biomarker that can be measured with immunoassays in cerebrospinal fluid and plasma and reflects axonal damage in a wide variety of neurological disorders.

Which is the most abundant neurofilament light protein?

NF-L is the most abundant of the three neurofilament proteins and, like the other nonepithelial intermediate filament proteins, it can form homopolymeric 10-nm filaments. “Effects of Charcot-Marie-Tooth-linked mutations of the neurofilament light subunit on intermediate filament formation.”

What is the purpose of neurofilament light chain?

Neurofilament light chain is a biomarker that can be measured with immunoassays in cerebrospinal fluid and plasma and reflects axonal damage in a wide variety of neurological disorders. It is a useful marker for disease monitoring in amyotrophic lateral sclerosis, multiple sclerosis, Alzheimer’s disease, and more recently Huntington’s disease.

What kind of protein is the NEFL protein?

Neurofilament light polypeptide ( NFL ), also known as neurofilament light chain, is a neurofilament protein that in humans is encoded by the NEFL gene. Neurofilament light chain is a biomarker that can be measured with immunoassays in cerebrospinal fluid and plasma and reflects axonal damage in…