What does it mean if Kappa-Lambda ratio is high?

26-‐1.65 The ratio of kappa to lambda is an important indicator. When one level (kappa or lambda)is high and the other is low, this is an indication that myeloma is active. If both kappa and lambda are increased, it can show a disease other than myeloma (like kidney disease).

What is the significance of Kappa-Lambda ratio?

The ratio or proportion between the kappa and lambda light chains indicates an excess production of one chain over the other, and therefore can be used as an indication of disease progression or remission.

What does it mean if your kappa light chain is high?

A free light chains test measures the amount of lambda and kappa free light chains in the blood. If the amount of free light chains is higher or lower than normal, it can mean you have a disorder of the plasma cells.

What is an abnormal kappa-lambda ratio?

An abnormal kappa-lambda FLC ratio indicates an excess of one light chain type versus the other, and is interpreted as a surrogate for clonal expansion based on extensive testing in healthy volunteers, and patients with myeloma, amyloidosis, and renal dysfunction.

What does a high Kappa/Lambra ratio mean?

FREE KAPPA/LAMBDA RATIO * . 26–1.65 The ratio of kappa to lambda is an important indicator. When one level (kappa or lambda)is high and the other is low, this is an indication that myeloma is active. If both kappa and lambda are increased, it can show a disease other than myeloma (like kidney disease).

What causes elevated Kappa free light chains?

Elevated kappa and lambda (K/L) free light chain (FLC) may occur due to polyclonal hypergammaglobulinemia or impaired renal clearance. A specific increase in FLC (eg, FLC K:L ratio) must be demonstrated for diagnostic purposes.

What is a free Kappa Lambda test?

The test measures the amount of free kappa and lambda light chains in the blood and calculates a kappa/lambda ratio. It does this to help detect, diagnose, and monitor conditions associated with an increased production of free light chains (FLC).

What is kappa light disease?

Kappa Light Chain Multiple Myeloma Treatment. Multiple myeloma is a rare form of cancer that begins in the bone marrow, when abnormal plasma cells accumulate and crowd out healthy blood cells. Healthy blood cells produce antibodies that help to fight infection.