What does high CrossLaps mean?

What does high CrossLaps mean?

Elevated levels of beta-C-terminal telopeptide (CTx) indicate increased bone resorption. Increased levels are associated with osteoporosis, osteopenia, Paget disease, hyperthyroidism, and hyperparathyroidism.

What is CrossLaps blood test?

A blood test for C-telopeptide (C-terminal telopeptide of type 1 collagen (CTx), Crosslaps) as a marker for bone resorption. A blood test for P1NP (Procollagen type 1 N-terminal propeptide) as a marker for bone formation.

What is normal CTx level?

Information on the serum CTX Test

CTX Value Risk for ONJ
300 to600 pg/ml (normal) none
150 to 299 pg/ml none to minimal
101 to 149 pg/ml moderate
Less than 100 pg/ml high

What does my CTx score mean?

C-terminal cross-linked telopeptide
CTX — which stands for C-terminal cross-linked telopeptide — is an indicator of bone turnover. But after menopause, as estrogen production wanes, resorption outpaces formation, and the turnover rate increases as formation tries to keep up. High bone turnover rates increase the risk for osteoporosis.

Is high bone turnover good or bad?

An increase in bone turnover seen with aging and pathological states such as osteoporosis leads to deterioration of bone microarchitecture and thus contributes to an increase in the risk of fracture independent of low bone mineral density (BMD).

Is bone turnover good or bad?

Bone turnover markers increase in proportion to fracture risk, independent of bone mineral density (BMD). In general, turnover markers also tend to be higher in patients with low bone density. However, this correlation is not absolute in individuals and this application of the test is most useful in population studies.

What is a NTx urine test?

Collagen Cross-Linked N-Telopeptide (NTx), Urine – NTx is useful to assess bone resorption in patients with metabolic bone disease. The test is also useful in monitoring therapy to slow or halt osteoporotic bone loss. A decline of 30% or more of NTx over a six-month period suggests effective therapy.

What is a bad bone density score?

A T-score of -1.0 or above is normal bone density. Examples are 0.9, 0 and -0.9. A T-score between -1.0 and -2.5 means you have low bone density or osteopenia. Examples are T-scores of -1.1, -1.6 and -2.4.

What increases bone turnover?

For example, after a fracture, markers may remain increased for up to 6 months. Other causes could include high turnover states such as hyperparathyroidism or hyperthyroidism, Paget disease, malignancy including myeloma, or advanced renal failure.

What is normal bone turnover rate?

2 to 3%/yr
The relatively low adult cortical bone turnover rate of 2 to 3%/yr is adequate to maintain biomechanical strength of bone. The rate of trabecular bone turnover is higher, more than required for maintenance of mechanical strength, indicating that trabecular bone turnover is more important for mineral metabolism.