How much mannitol do you give?

The usual adult dosage ranges from 50 to 200 g in a 24-hour period, but in most instances an adequate response will be achieved at a dosage of approximately 100 g/24 hours. The rate of administration is usually adjusted to maintain a urine flow of at least 30 to 50 mL/hr.

What is mannitol infusion used for?

Mannitol I.V. (mannitol injection) is a diuretic used to increase urine production, and to treat or prevent medical conditions that are caused by an increase in body fluids/water (e.g., cerebral edema, glaucoma, kidney failure).

What is 20% mannitol used for?

Mannitol 20% Infusion is a medicine used in the treatment of acute renal (kidney) failure, cerebral edema (accumulation of excessive fluid in the brain) and to reduce the pressure inside the eyes in a condition called glaucoma.

How do you mix mannitol?

Add the contents of two 50-mL vials of 25% mannitol injection to 900 mL of Sterile Water for Injection to make a 2.5% irrigating solution. Only use clear solutions.

How long can mannitol be given?

Conclusions: Mannitol use every 4 hours per day has evident effect of reducing the intracranial pressure in the 1st, 2nd, 3rd, and 4th day, then mannitol should be used temporarily according to the intracranial pressure after the 5th day. Mannitol should not be used for more than 8 days.

What are side effects of mannitol?

COMMON side effects

• dry mouth.
• excessive thirst.
• headache.
• nausea.
• vomiting.
• excess urination.

How quickly does mannitol work?

For increased intraocular pressure, dosages typically range from 0.25 g/kg to 2 g/kg administered intravenously over 30 to 60 minutes with effect within 5 to 10 minutes and lasting up to approximately 6 hours.

When should mannitol be stopped?

Mannitol administration should stop if significant electrolyte abnormalities develop or the osmolality reaches 320 mOsm or higher.