How is the spectrin family related to actin?

Spectrin is related to a large superfamily of actin cross-linking proteins that all share the CH domain actin binding motif. A closer-knit spectrin family of proteins shares the same general domain structure and molecular shape as human erythrocyte spectrin.

Are there any proteins that bind to actin?

Many actin-binding proteins, including α-actinin, β-spectrin, dystrophin, utrophin and fimbrin, do this through the actin-binding calponin homology domain. This is a list of actin-binding proteins in alphabetical order.

What kind of protein is Actinin alpha 1?

87 – Gene ResultACTN1 actinin alpha 1 [ (human)] Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types.

How is the spectrin family related to erythrocyte?

Spectrin is related to a large superfamily of actin cross-linking proteins that all share the CH domain actin binding motif. A closer-knit spectrin family of proteins shares the same general domain structure and molecular shape as human erythrocyte spectrin. In humans there are five known β spectrin genes and two α genes.

Is the human spectrin family the same as erythrocytes?

A closer-knit spectrin family of proteins shares the same general domain structure and molecular shape as human erythrocyte spectrin. In humans there are five known β spectrin genes and two α genes. The α I and β I spectrin genes are primarily expressed in erythrocytes but are also expressed in muscle and some cells in the brain.

How many genes are in the spectrin gene family?

The spectrin gene family has undergone expansion during evolution. Rather than the one α and two β genes in invertebrates, there are two α spectrins (αI and αII) and five β spectrins (βI to V), named in the order of discovery. In humans, the genes are: The production of spectrin is promoted by the transcription factor GATA1 .

Where are the spectrin proteins found in the body?

Spectrin family proteins represent an important group of actin-bundling and membrane-anchoring proteins found in diverse structures from yeast to man. Arising from a common ancestral α -actinin gene through duplications and rearrangements, the family has increased to include the spectrins and dystrophin⧸utrophin.