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How does perchlorate affect the thyroid?

How does perchlorate affect the thyroid?

At high levels, perchlorate can inhibit the function of the thyroid gland, leading to hypothyroidism in adults. Now, a large study published yesterday in Environmental Health Perspectives shows that much lower levels of perchlorate, traditionally considered safe, can be detrimental to thyroid function in women.

Does sodium valproate affect thyroid?

Conclusions: Valproate monotherapy may cause significant alteration in thyroid profile in children with epilepsy, occurring early in the course of treatment and persisting as long as VPA is initiated.

Is tapioca good for hypothyroidism?

The thiocyanate in tapioca can be quite harmful for thyroid patients. However, you could pair boiled tapioca with delicious fish curry as fish is a rich source of iodine.

Is bok choy good for thyroid?

Raw bok choy, like all cruciferous vegetables, contains an enzyme called myrosinase. Myrosinase can hinder thyroid function by preventing the body from absorbing iodine. Cooking deactivates it. Eating raw bok choy in moderate amounts does not pose a hazard.

Does perchlorate have iodine?

Perchlorate is an inorganic anion that is a potent competitive inhibitor of the sodium-iodide symporter (NIS) found on the basolateral membrane of thyroid cells. In pharmacological doses, perchlorate decreases the active transport of iodine into the thyroid.

Can epilepsy medicine cause thyroid problems?

Thyroid hormones may fluctuate with exposure to antiepileptic drugs. The use of certain antiepileptic drugs may cause alterations in thyroid hormone levels in patients with epilepsy.

Does Keppra affect thyroid?

[8,9] In addition, one study demonstrated that levetiracetam had no effects on thyroid hormone levels than compared to other conventional antiepileptics.

Should Cabbage be avoided in hypothyroidism?

So if you do, it’s a good idea to limit your intake of Brussels sprouts, cabbage, cauliflower, kale, turnips, and bok choy, because research suggests digesting these vegetables may block the thyroid’s ability to utilize iodine, which is essential for normal thyroid function.

What does potassium perchlorate do to the thyroid?

Potassium perchlorate is a competitive inhibitor of iodine uptake through inhibiting the sodium-iodide symporter ( NIS) on the thyroid follicular cell membrane. This results in a potential decrease in thyroid hormone synthesis including thyroxine (T4) and tri-iodothyronine (T3).

Why is perchlorate bad for the thyroid in infants?

The reason is because as I mentioned earlier, perchlorate inhibits iodine uptake, and the same study I just mentioned also measured the levels of iodide, and found that the presence of perchlorate in the milk lowers the iodine content and may impair thyroid development in infants.

How is chlorate and perchlorate related in hypochlorite?

Thus, the observed increase of chlorate is in reality a combined function of chlorate production and chlorate oxidation to perchlorate. Additionally, the rate of perchlorate formation is depen- dent on factors other than hypochlorite and chlorate concentrations including ionic strength and temperature.

When did perchlorate stop being used for hyperthyroidism?

So this in turn can lead to a hypothyroid condition. In fact, perchlorate was used as an antithyroid drug for hyperthyroidism in the 1950s and 1960s, but was discontinued because of the occasional occurrence of aplastic anemia (6) .